Abstract N-(2-Bromopropionyl)-O-benzyl-L-serine (BPBS) was prepared using 2-bromopropionic acid
\nand N-Boc-O-Bzl-L-serine as the starting reagents. BPBS underwent the intra-molecular ring-closing reac-
\ntion in DMF\/Et
\n3
\nN solvent at 80 \u2103for 9 h forming a mixture of two non-enantiomers, i.e. (3S,6S)-benzyl-
\noxymethyl-6-methyl-morpholine-2,5-dione [(3S,6S)-BMMD] and (3S,6R)-BMMD with a yield of 70%. Two
\noptically pure enantiomers of BMMD, i.e. (3S,6S)-BMMD and (3S,6R)-BMMD were obtained via 4 opera-
\ntion circles of \u201csolution-partial recrystallization\u201d by means of a differential recrystallization method using
\nethyl acetate as a solvent. The single crystals of the two isomers of BMMD were grown from ethyl acetate at
\nroom temperature. The fine molecular structures of the two isomers were determined by X-ray diffraction
\nanalysis of the single crystals.
\nKeywords (3S,6S)-benzyloxymethyl-6-methyl-morpholine-2,5-dione; (3S,6R)-benzyloxymethyl-6-methyl-
\nmorpholine-2,5-dione; resolution; optical isomer; crystal structure <\/p>\n","raw":"","protected":false},"excerpt":{"rendered":"
Abstract N-(2-Bromopropionyl)-O-benzyl-L-serine (BPBS) was prepared using 2-bromopropionic acid and N-Boc-O-Bzl-L-serine as the starting reagents. BPBS underwen …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"post_thumbnail_image":"","content_first_image":"","post_medium_image_300":"","post_thumbnail_image_624":"","post_frist_image":"","post_medium_image":"","post_large_image":"","post_full_image":"","post_all_images":[],"videoAdId":"","listAd":"0","listAdId":"","listAdEvery":5,"total_comments":0,"category_name":"\u4ea7\u54c1\u65b0\u95fb","post_date":"2017-10-10","like_count":"0","praiseWord":"\u9f13\u52b1","copyright_state":"","excitationAd":"0","rewardedVideoAdId":"","detailAdId":"","detailAd":"0","enterpriseMinapp":"0","audios":[],"postImageUrl":"https:\/\/sienw.com\/wp-content\/uploads\/2023\/10\/1-9.jpg","avatarurls":[],"related_posts":null,"pageviews":40,"next_post_id":114,"next_post_title":"(3S,6S)-\u53ca(3S,6R)-3-\u82c4\u6c27\u7532\u57fa-6-\u7532\u57fa-\u5417\u5549-2,5-\u4e8c\u916e\u7684\u5236\u5907","previous_post_id":null,"previous_post_title":null,"_links":{"self":[{"href":"https:\/\/sienw.com\/index.php\/wp-json\/wp\/v2\/posts\/112"}],"collection":[{"href":"https:\/\/sienw.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sienw.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sienw.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sienw.com\/index.php\/wp-json\/wp\/v2\/comments?post=112"}],"version-history":[{"count":1,"href":"https:\/\/sienw.com\/index.php\/wp-json\/wp\/v2\/posts\/112\/revisions"}],"predecessor-version":[{"id":113,"href":"https:\/\/sienw.com\/index.php\/wp-json\/wp\/v2\/posts\/112\/revisions\/113"}],"wp:attachment":[{"href":"https:\/\/sienw.com\/index.php\/wp-json\/wp\/v2\/media?parent=112"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sienw.com\/index.php\/wp-json\/wp\/v2\/categories?post=112"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sienw.com\/index.php\/wp-json\/wp\/v2\/tags?post=112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}